RNA Splicing Regulation
Gene co-expression module in Tuft cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
DDX5 and DDX17 are DEAD-box RNA helicases involved in pre-mRNA splicing and transcriptional regulation. SRRM2 is a serine/arginine repetitive matrix protein central to splicing speckles. PRPF4B is a pre-mRNA processing kinase. RSRP1 is a splicing regulatory protein. CHD9 is a chromatin remodeler. TLE4 is a Groucho/TLE transcriptional co-repressor. ZFHX3 is a zinc finger homeobox transcription factor. Together these define an RNA splicing and chromatin/transcriptional regulation program. B4GALNT4 is tuft-enriched but may reflect co-regulation. The module is consistent with post-transcriptional gene regulation active in tuft cells during CD inflammation.
Genes
Most correlated modules
- Tuft PI3K-Src Signaling · correlation 0.92
- Tuft Chemosensory Receptor · correlation 0.89
- Tuft Cell Identity · correlation 0.89
- Tuft Microvilli Identity · correlation 0.84
- Tuft Surface Identity · correlation 0.82
- Tuft Cell Identity · correlation 0.82
- Tuft Chemosensory Signaling · correlation 0.80
- Tuft Calcium Signaling · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.