Eicosanoid Inflammatory Modulation
Gene co-expression module in Tuft cells
| Category | Inflamation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include TIMP1 (tissue inhibitor of metalloproteinases, ECM remodeling/inflammation), ALOX5AP (5-lipoxygenase activating protein, leukotriene biosynthesis — neighbor to M25's ALOX5), HTR3C (serotonin receptor type 3C, tuft cell neurotransmitter signaling), GLRX (glutaredoxin, redox regulation), KRT7 (keratin 7, epithelial structural), PAK3 (p21-activated kinase, cytoskeletal/signaling), SELENOM (selenoprotein M, ER redox), SEMA7A (semaphorin 7A, immune modulation), SERPINA1 (alpha-1 antitrypsin, protease inhibitor/anti-inflammatory), LMCD1 (LIM and cysteine-rich domains), DPYSL3 (dihydropyrimidinase-like, cytoskeletal), HLA-A (MHC-I, immune presentation), ZNF428, LY6H. The module bridges tuft cell eicosanoid/serotonin signaling (ALOX5AP, HTR3C) with protease inhibition and redox regulation, suggesting an inflammatory-modulatory secretory program. Neighbor to M25 (core tuft identity), sharing leukotriene pathway genes.
Genes
Most correlated modules
- Tuft Secretory Processing · correlation 0.90
- Type I Interferon · correlation 0.75
- Tuft Lipid Secretion · correlation 0.73
- Tuft Chemosensory Transduction · correlation 0.67
- Tuft GPCR Signaling · correlation 0.58
- Lipid Metabolite Transport · correlation 0.52
- Cholinergic Tuft Signaling · correlation 0.45
- Tuft Cell Identity · correlation 0.43
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.