Tuft PI3K-Src Signaling
Gene co-expression module in Tuft cells
| Category | Cehmical sensing |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
HCK (Src-family kinase, among the most tuft-enriched genes in the colon), SPIB (ETS transcription factor essential for tuft cell differentiation), PIK3CG (PI3K gamma, key tuft cell signaling kinase), AFAP1L2 (actin filament-associated protein, tuft-enriched), and ADGRG6 (adhesion GPCR, tuft-enriched) define the core tuft cell transcriptional and kinase signaling identity. SPTLC2 and LIPG contribute lipid metabolism. EPS8L2 links to actin/brush border. This module captures the tuft cell lineage-defining transcription factor and PI3K/Src kinase signaling program, strongly upregulated in CD inflammation.
Genes
Most correlated modules
- Tuft Microvilli Identity · correlation 0.93
- RNA Splicing Regulation · correlation 0.92
- Tuft Chemosensory Receptor · correlation 0.91
- Tuft Cell Identity · correlation 0.90
- Tuft Surface Identity · correlation 0.87
- Tuft Cell Identity · correlation 0.86
- Tuft Chemosensory Signaling · correlation 0.84
- Tuft Calcium Signaling · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.