ER Membrane Biogenesis
Gene co-expression module in Tuft cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
This module is more heterogeneous than its neighbors. SDHD (Complex II/succinate dehydrogenase subunit D) and HIGD1A (Complex IV regulator under hypoxia) link to mitochondrial respiration. SPCS2, ERP29, DPM3, and KDELR1-neighbor TECR point to ER membrane and glycosylation. VSIG2 and PRAC1 are colon epithelial identity markers enriched in pre_tuft. PYURF (pyrimidine biosynthesis), LAPTM4A (lysosomal), TSPAN3 (membrane), PPP1CA (phosphatase), MTCH2 (mitochondrial carrier/apoptosis), COMT (catecholamine metabolism), SNRPC (spliceosome) are diverse housekeeping genes. The unifying theme across this pre_tuft-enriched module is general epithelial housekeeping with ER/membrane biogenesis, representing the biosynthetic infrastructure of pre-tuft progenitors.
Genes
Most correlated modules
- ATP Synthase OxPhos · correlation 0.98
- Mitochondrial Translation · correlation 0.98
- Mitochondrial Biogenesis · correlation 0.97
- RNA Splicing Translation · correlation 0.97
- Mitochondrial OxPhos Complex I · correlation 0.97
- Pre-tuft Mitochondrial Metabolic · correlation 0.96
- Pre-tuft Biosynthetic · correlation 0.96
- Protein Folding Proteostasis · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.