EFNB2 — Ephrin B2
EFNB2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EFNB2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T Cell Signaling B cell help | CCDC6, ELMO1, ETS1, MYO5A, PTPN11, RABGAP1L, SFXN1, SH2D1A +4 more | View in SCUBA |
| Endothelial | Notch Arterial Identity Endothelial cell development | ADAMTS1, ARID5A, BTG1, BTG2, CRIP1, DLL4, EFNA1, GADD45A +14 more | View in SCUBA |
| Enterocytes | ER chaperone/UPR Protein processing & ER | ANXA2, CALR, ENO1, HSP90B1, HSPA5, MARCKS, ME1, PDIA3 +3 more | View in SCUBA |
| Lymphatic endothelial | Collecting Lymphatic Identity migration & adhesion | CCDC141, EPB41, FBXO34, FGD6, GUCY1A1, ITGA6, MDFIC, NAV1 +13 more | View in SCUBA |
| Pericytes | Arterial Notch Signaling Developmental | BCL6B, CYTH1, DLL4, HEY1, MSX1, NEDD9, PNP, SGK1 +1 more | View in SCUBA |
About the gene
| Synonyms | EPLG5, Htk-L, HTKL, LERK5, MGC126226, MGC126227, MGC126228 |
|---|---|
| Chromosome | 13: 106489745-106535662 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted membrane proteins |
| Molecular function | Developmental protein, Host cell receptor for virus entry, Receptor |
| Biological process | Angiogenesis, Differentiation, Host-virus interaction, Neurogenesis |
Function
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.