DICER1 — Dicer 1, ribonuclease III
DICER1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DICER1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | JNK/MAPK Stress Signaling Stress | ABTB3, BICRAL, COP1, ELMO1, ERC1, FBXO11, FCHSD2, FGFR1 +19 more | |
| Macrophages | Chromatin Transcriptional Regulation Housekeeping | AGO1, ARID1A, CARD8, CEPT1, CLOCK, CPSF7, CTNND1, DCAF10 +19 more | View in SCUBA |
About the gene
| Synonyms | Dicer, HERNA, K12H4.8-LIKE, KIAA0928, MNG1 |
|---|---|
| Chromosome | 14: 95086228-95158010 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Endonuclease, Helicase, Hydrolase, Nuclease, RNA-binding |
| Biological process | Host-virus interaction, RNA-mediated gene silencing |
Function
Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.