AGO4 — Argonaute RISC component 4
AGO4 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AGO4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T cell co-receptors T cell development | ARRB2, CAPG, CD200R1, CD40LG, CD96, EMB, FKBP11, GAB3 +13 more | View in SCUBA |
| Neutrophils | Signal Attenuation Innate immunity | CAB39, CBL, EXOC6, NPEPPS, PIK3CD, RNF24, SPOPL, ZNF516 |
About the gene
| Synonyms | EIF2C4, FLJ20033, hAGO4, KIAA1567 |
|---|---|
| Chromosome | 1: 35808016-35857890 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Ribonucleoprotein, RNA-binding |
| Biological process | RNA-mediated gene silencing, Translation regulation |
Function
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.