EXOC6 — Exocyst complex component 6
EXOC6 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EXOC6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Arterial EC Homeostasis Endothelial cell development | APOL3, BMX, FAXDC2, FTH1, GABARAPL1, GAS6, GIMAP1, GIMAP4 +10 more | View in SCUBA |
| Neutrophils | Signal Attenuation Innate immunity | AGO4, CAB39, CBL, NPEPPS, PIK3CD, RNF24, SPOPL, ZNF516 | |
| Pericytes | Vascular Identity TFs Developmental | CCDC85A, GIPC2, HHEX, MCTP1, SLC16A14, SOX7, THSD7A, TSPAN7 | View in SCUBA |
About the gene
| Synonyms | DKFZp761I2124, EXOC6A, FLJ1125, MGC33397, Sec15, SEC15L, SEC15L1 |
|---|---|
| Chromosome | 10: 92826831-93059493 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Transporters |
| Biological process | Exocytosis, Protein transport, Transport |
Function
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.