CAPG — Capping actin protein, gelsolin like

CAPG belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CAPG's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Cytoskeleton/motility migration & adhesion	ANXA2, ANXA4, BHLHE41, C4orf48, CAPN2, CIB1, ISCU, LGALS1 +11 more	View in SCUBA
CD4⁺ T cells	T cell co-receptors T cell development	AGO4, ARRB2, CD200R1, CD40LG, CD96, EMB, FKBP11, GAB3 +13 more	View in SCUBA
CD8⁺ T cells	Tc17 program Tc17 program	ABI3, ABRACL, CCDC85B, FKBP11, GPR34, IL17A, KLRB1, NFKBIA +4 more	View in SCUBA
Endothelial	Inflammatory EC Activation ECM remodeling	C4orf48, CD200, COL6A1, COL6A2, IGFBP5, LAMP3, NT5E, OAF +4 more	View in SCUBA
Gamma-delta T cells	Gut-homing Residence Tissue residence	ADAM28, ASB2, ATP8B4, CCR9, CD101, CD9, DAPK2, DENND1B +8 more
Hematopoietic progenitor cells	MHC-I Antigen Presentation Myeloid development	ACTB, B2M, CALM2, CYBA, EVI2A, EVI2B, FUT7, HLA-A +10 more
Innate lymphoid cells	NK Homing Circulating Homing & TEM	ADD3, ANXA1, APOBEC3G, C16orf54, C1orf162, CASP4, CAST, CDKN2D +37 more	View in SCUBA
Macrophages	Oxidative Metabolic Program Mitochondrial & OxPhos	ACADM, CA2, CALM3, COQ2, CSRP1, CSTB, DENND2D, EIF4EBP1 +29 more	View in SCUBA
Monocytes	Classical Monocyte Activation Inflammatory	LGALS1, LYZ, MCEMP1, PDLIM7, S100A8, S100A9, SERPINB1, TALDO1 +1 more	View in SCUBA
Mucosal-associated invariant T cell	Heat Shock Response Stress	AHSA1, BAG3, CACYBP, CHORDC1, CSF1, DNAJA4, DNAJB4, GPR174 +13 more
Natural Killer cells	NK Cytoskeletal Activation Cytoskeleton & motility	CLNK, COTL1, EVL, GPR82, ITM2A, PEBP1, PGK1, PLEKHO1 +3 more	View in SCUBA

About the gene

Synonyms	AFCP, MCP
Chromosome	2: 85394753-85418432
Predicted location	Intracellular
Essential gene	No
Protein class	Plasma proteins, Predicted intracellular proteins
Molecular function	Actin capping, Actin-binding

Function

Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.