Signal Attenuation
Gene co-expression module in Neutrophils
| Category | Innate immunity |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
CBL is an E3 ubiquitin ligase that mediates receptor ubiquitination and signal termination. PIK3CD (PI3K-delta) is a key lipid kinase in immune cell signaling downstream of immune receptors. AGO4 is an Argonaute family member involved in miRNA-mediated post-transcriptional silencing. SPOPL is a Cullin-RING ubiquitin ligase adaptor. CAB39 activates AMPK. Together, these genes form a signal regulation module combining ubiquitin-proteasome pathway, PI3K signaling, and miRNA-mediated post-transcriptional control, consistent with a receptor signal attenuation/homeostasis program.
Genes
AGO4, CAB39, CBL, EXOC6, NPEPPS, PIK3CD, RNF24, SPOPL, ZNF516
Most correlated modules
- Stress Kinase Signaling · correlation 0.98
- Actin Cytoskeletal Remodeling · correlation 0.96
- JAK-MAPK Signaling · correlation 0.96
- ELMO-DOCK Chemotaxis · correlation 0.94
- Degranulation Trafficking · correlation 0.94
- Ubiquitin-Proteasome Turnover · correlation 0.93
- Cytoskeletal Remodeling · correlation 0.92
- ER Stress Response · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.