AKR1B1 — Aldo-keto reductase family 1 member B
AKR1B1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AKR1B1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | MMP-driven Fibroblast Remodeling ECM remodeling | ANPEP, COL27A1, COL7A1, CTSL, IL7R, INHBA, MME, MMP1 +4 more | View in SCUBA |
| Macrophages | Translation Initiation Housekeeping | CAMLG, CAPZB, EEF1D, EEF2, EID1, EIF3D, EIF3E, EIF3F +26 more | View in SCUBA |
| Monocytes | Efferocytosis Tissue Macrophage Lysosomal & pahgocytosis | ADORA3, CPM, FCHO2, GPR34, MERTK, PDK4, SLC1A3, STARD13 | View in SCUBA |
About the gene
| Synonyms | ALDR1, AR |
|---|---|
| Chromosome | 7: 134442356-134459284 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Lipid metabolism |
Function
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2- (5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS- carbonyls).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.