EID1 — EP300 interacting inhibitor of differentiation 1
EID1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EID1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Oxidative Phosphorylation Mitochondrial & OxPhos | AP2S1, ATP5F1C, ATP5PF, COPS9, COX6B1, FAM89B, FDPS, FIS1 +19 more | View in SCUBA |
| Endothelial | ER-Golgi Trafficking Protein processing & ER | ATL3, DIAPH2, ECE1, GOLIM4, KTN1, MAGT1, PGK1, SHISA5 +4 more | View in SCUBA |
| Gamma-delta T cells | mRNA Splicing Processing RNA processing & translation | ARHGEF1, BECN1, CCNI, DENND4B, HNRNPA0, HNRNPDL, KLHDC4, LENG8 +18 more | |
| Glial cells | Lysosomal Sphingolipid Metabolism Housekeeping | ASAH1, BEX4, CLIC4, LAMP1, PSAP, SERPINB6, SGCE, SSPN | View in SCUBA |
| Lymphatic endothelial | Metabolic Housekeeping Housekeeping | CAPNS1, CYB5R3, DMAC1, DUT, ESD, GNAI2, ISCU, OCIAD1 +5 more | View in SCUBA |
| Macrophages | Translation Initiation Housekeeping | AKR1B1, CAMLG, CAPZB, EEF1D, EEF2, EIF3D, EIF3E, EIF3F +26 more | View in SCUBA |
| Smooth muscle cells | OxPhos & proteasome Mitochondrial & OxPhos | CD151, CHCHD2, COX5B, NDUFA11, NDUFB2, NDUFB9, NEDD8, PARK7 +8 more | View in SCUBA |
About the gene
| Synonyms | C15orf3, CRI1, EID-1 |
|---|---|
| Chromosome | 15: 48878134-48880173 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Repressor |
| Biological process | Cell cycle, Differentiation, Transcription, Transcription regulation |
Function
Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.