MMP-driven Fibroblast Remodeling
Gene co-expression module in Fibroblasts
| Category | ECM remodeling |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes include RUNX2 (master osteogenic/mesenchymal transcription factor), MMP3 and MMP1 (matrix metalloproteinases, ECM degradation/remodeling), INHBA (activin A, TGF-β superfamily, fibrosis/inflammation), COL7A1 and COL27A1 (collagens), MME (neprilysin/CD10, stromal marker), ANPEP (CD13, stromal/mesenchymal marker), SLC16A3 (lactate transporter, metabolic reprogramming), IL7R (cytokine receptor), CTSL (cathepsin L, proteolysis). The combination of RUNX2, MMP1, MMP3, INHBA, and collagens in inflamed intestinal fibroblasts points to an activated mesenchymal/fibrogenic remodeling program. MMP1/MMP3 are classic inflammatory fibroblast effectors. Upregulated in both UC and CD inflammation.
Genes
AKR1B1, ANPEP, COL27A1, COL7A1, CTSL, IL7R, INHBA, MME, MMP1, MMP3, RUNX2, SEZ6L2, SLC16A3
Most correlated modules
- TGF-beta Fibrosis · correlation 0.80
- Hypoxia Response · correlation 0.79
- IL-1 Receptor Signaling · correlation 0.78
- Inflammatory Fibroblast Activation · correlation 0.74
- Activated Myofibroblast State · correlation 0.72
- Inflammatory Fibroblast Activation · correlation 0.67
- Chemokine-secreting Fibroblasts · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.