Translation Initiation
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 35 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 35 genes have a known function matching the annotation |
Why this annotation
Four eIF3 subunits (EIF3H, EIF3F, EIF3E, EIF3L) are among the top hub genes, alongside translation elongation factors EEF2 and EEF1D — this is a clear translation initiation/elongation signature. RAC1 and RHOG (Rho GTPases) and CAPZB (actin capping protein) add a cytoskeletal component. NSA2 and POLR1D support ribosome biogenesis. MRPS28 (mitoribosome) and SEC11A (signal peptidase) are peripheral. The dominant program is cytoplasmic translation machinery. In the context of neighboring modules with OXPHOS and housekeeping genes, this module represents the translational arm of the housekeeping program.
Genes
AKR1B1, CAMLG, CAPZB, EEF1D, EEF2, EID1, EIF3D, EIF3E, EIF3F, EIF3H, EIF3L, ERCC1, FAAP20, GDI2, GNAS, GPSM3, HNRNPA1, MRFAP1, MRPS28, NSA2, OSTF1, OXA1L, POLR1D, PSMF1, RAC1, RALBP1, RGS19, RHOG, SEC11A, SERP1, SPI1, ST13, TLN1, TMEM219, TOMM20
Most correlated modules
- RNA Processing & Repair · correlation 0.92
- Mitochondrial Complex Assembly · correlation 0.90
- Protein Homeostasis Mixed · correlation 0.89
- Lysosomal Hydrolase Program · correlation 0.87
- Complex I / NADH Dehydrogenase · correlation 0.86
- Macrophage Proliferation · correlation 0.85
- Mitochondrial OXPHOS · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.