Chylomicron apolipoprotein assembly
Gene co-expression module in Enterocytes
| Category | Lipid metabolism |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Small-intestine-like apolipoprotein and xenobiotic program: APOA1, APOA4, APOC3, CYP3A4, ENPP3 and ARG2. This likely reflects ileal-type or metaplastic enterocytes, or proximal colon cells, that secrete chylomicrons. It shares the lipid theme with M28.
Genes
APOA1, APOA4, APOC3, ARG2, CYP3A4, ENPP3, FLVCR1, RMDN3, THSD4
Most correlated modules
- Crypt-top colonocyte · correlation 0.90
- Amino acid absorption · correlation 0.89
- Mature enterocyte differentiation · correlation 0.88
- Brush border lipid handling · correlation 0.88
- Endocytic nutrient uptake · correlation 0.87
- ER-autophagy homeostasis · correlation 0.87
- Enterocyte lipid trafficking · correlation 0.84
- Long-gene transcript bias · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.