THSD4 — Thrombospondin type 1 domain containing 4
THSD4 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
THSD4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | YAP Mechanotransduction migration & adhesion | COBLL1, CREB5, DEPP1, DST, FGL2, FLNC, FN1, GCNT2 +7 more | View in SCUBA |
| Enterocytes | Chylomicron apolipoprotein assembly Lipid metabolism | APOA1, APOA4, APOC3, ARG2, CYP3A4, ENPP3, FLVCR1, RMDN3 | View in SCUBA |
| Smooth muscle cells | Microfibril ECM Assembly ECM remodeling | ADAM28, FBN2, ITGA9, NEO1, NID1, PROM1, PSD3, SERPINE2 +2 more | View in SCUBA |
About the gene
| Synonyms | ADAMTSL6, FLJ13710, FVSY9334, PRO34005 |
|---|---|
| Chromosome | 15: 71096952-71783383 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted secreted proteins |
| Molecular function | Hydrolase |
Function
Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.