ARAP3 — ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARAP3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARAP3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Pericytes | Rho GTPase Signaling Cytoskeletal | ARHGEF15, HPCAL1, NOVA2, PLCB1, PPP1R13B, PRKD2, RAPGEF3 | View in SCUBA |
About the gene
| Synonyms | CENTD3, DRAG1, FLJ21065 |
|---|---|
| Chromosome | 5: 141653401-141682230 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | GTPase activation |
Function
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase- activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.