Rho GTPase Signaling
Gene co-expression module in Pericytes
| Category | Cytoskeletal |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes ARAP3 (ArfGAP/RhoGAP), ARHGEF15 (RhoGEF), RAPGEF3 (EPAC1/cAMP-Rap1), NOVA2 (vascular splicing regulator), PRKD2, and PLCB1 collectively define a Rho/Arf GTPase and second-messenger signaling program active in pericytes and endothelial cells for vascular tone and cytoskeletal regulation. NOVA2 specifically regulates alternative splicing of angiogenic transcripts. The module is downregulated during intestinal inflammation and recovers in remission, consistent with a homeostatic vascular signaling identity program. Neighbor context (M49, M26 are endothelial) supports a vascular cell signaling interpretation.
Genes
ARAP3, ARHGEF15, HPCAL1, NOVA2, PLCB1, PPP1R13B, PRKD2, RAPGEF3
Most correlated modules
- Angiogenic Receptor Signaling · correlation 0.98
- Vascular Permeability · correlation 0.98
- Pericyte Contractile Tone · correlation 0.98
- Vascular Pericyte Identity · correlation 0.98
- BMP-SMAD Signaling · correlation 0.97
- MHC-II Antigen Presentation · correlation 0.97
- Vascular Junction Adhesion · correlation 0.96
- Vascular Tone Homeostasis · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.