ARHGEF15 — Rho guanine nucleotide exchange factor 15
ARHGEF15 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARHGEF15's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Lipid Signaling migration & adhesion | A2M, ADGRG1, CNOT6L, CYYR1, DIP2B, HIP1R, PCDH1, PITPNC1 +3 more | View in SCUBA |
| Pericytes | Rho GTPase Signaling Cytoskeletal | ARAP3, HPCAL1, NOVA2, PLCB1, PPP1R13B, PRKD2, RAPGEF3 | View in SCUBA |
About the gene
| Synonyms | ARGEF15, FLJ13791, KIAA0915, MGC44868, Vsm-RhoGEF |
|---|---|
| Chromosome | 17: 8310241-8322514 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | GTPase activation, Guanine-nucleotide releasing factor |
Function
Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse- promoting activity of EPHB2
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.