PLCB1 — Phospholipase C beta 1
PLCB1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLCB1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytokine signaling Immune regulation | ABCB1, ARHGEF40, AUTS2, COLQ, DSE, ERN1, GPR65, IFI44 +12 more | View in SCUBA |
| Endothelial | Endothelial Lipid Signaling migration & adhesion | A2M, ADGRG1, ARHGEF15, CNOT6L, CYYR1, DIP2B, HIP1R, PCDH1 +3 more | View in SCUBA |
| Gamma-delta T cells | T Cell Development T cell maturation | ANK3, ATF7IP2, CERK, ERN1, FKBP11, LRIG1, MICAL2, PAG1 +4 more | |
| Hematopoietic progenitor cells | Multipotent Progenitor State Stemness | CD44, CD99, FLT3, GBP2, GLIPR1, IL6R, PRAM1, PROM1 | |
| Mucosal-associated invariant T cell | Calcineurin-NFAT Signaling TCR Signaling | AKT3, CDC14A, IQGAP2, NCALD, NEK7, PLCL2, PPP2R2B, PPP3CA +3 more | |
| Pericytes | Rho GTPase Signaling Cytoskeletal | ARAP3, ARHGEF15, HPCAL1, NOVA2, PPP1R13B, PRKD2, RAPGEF3 | View in SCUBA |
| Smooth muscle cells | Cytoskeletal Scaffolding Cytoskeletal | AKAP6, C3orf70, CNST, CTTNBP2, DACT3, IQGAP1, KIF13A, KLHL23 +8 more | View in SCUBA |
About the gene
| Synonyms | KIAA0581, PLC-I, PLC154 |
|---|---|
| Chromosome | 20: 8077251-8968360 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase, Transducer |
| Biological process | Lipid degradation, Lipid metabolism |
Function
Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5- bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein- coupled receptors. Regulates the function of the endothelial barrier.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.