PPP1R13B — Protein phosphatase 1 regulatory subunit 13B
PPP1R13B belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPP1R13B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | MAPK-ERK Signaling migration & adhesion | ARIH1, BRAF, CPNE8, DENND4A, ELF2, FBXO11, FNDC3B, GRB10 +6 more | View in SCUBA |
| Pericytes | Rho GTPase Signaling Cytoskeletal | ARAP3, ARHGEF15, HPCAL1, NOVA2, PLCB1, PRKD2, RAPGEF3 | View in SCUBA |
About the gene
| Synonyms | ASPP1, KIAA0771, p53BP2-like, p85 |
|---|---|
| Chromosome | 14: 103733195-103847575 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Biological process | Apoptosis |
Function
Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.