Crypt Colonocyte Identity
Gene co-expression module in Colonocytes
| Category | Epithelial development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 45 genes have a known function matching the annotation |
Why this annotation
Hub genes include EPHB2 (Wnt-regulated receptor tyrosine kinase marking crypt progenitor position along the crypt-surface axis), CDCA7 (Wnt target, proliferation), FOXA2 (pioneer transcription factor for intestinal identity), AQP1 (water channel), RARRES2 (chemerin, expressed in colon epithelium), NUPR1 (stress-responsive transcription factor), PTGDR (prostaglandin D2 receptor), KCNN4 (calcium-activated potassium channel, ion transport), WNK4 (ion transport kinase), ATP2C2 (calcium pump), SLC39A8 (zinc transporter), ST6GAL1 (sialylation enzyme), KCTD12 (potassium channel regulator), PRAC1 (colon-specific), PKDCC (kinase). The strong enrichment in crypt colonocytes and the combination of Wnt-target positional markers (EPHB2, CDCA7) with ion transport genes suggests this module captures the crypt colonocyte positional identity program with associated ion/water transport functions.
Genes
Most correlated modules
- Ribosome Biogenesis · correlation 0.89
- DNA Repair Housekeeping · correlation 0.87
- Mitochondrial Biogenesis · correlation 0.86
- Pre-mRNA Splicing · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.