ARHGAP32 — Rho GTPase activating protein 32
ARHGAP32 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARHGAP32's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Apical junction complex Migration & adhesion | HEPH, KDM6A, KIAA1671, MYH14, NIPBL, PLEKHA7, POF1B, RBBP8 +3 more | View in SCUBA |
About the gene
| Synonyms | GC-GAP, GRIT, KIAA0712, MGC1892, RICS |
|---|---|
| Chromosome | 11: 128965060-129279324 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins |
| Molecular function | GTPase activation |
Function
GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.