Apical junction complex
Gene co-expression module in Enterocytes
| Category | Migration & adhesion |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 12 genes have a known function matching the annotation |
Why this annotation
Hubs HEPH, PLEKHA7, POF1B, MYH14 and ARHGAP32 mark a mature enterocyte apical and junctional program. PLEKHA7 anchors the zonula adherens, MYH14 is the brush-border and junctional myosin, and POF1B is an epithelial junction actin-binder. HEPH is the basolateral ferroxidase for iron export, and SLC20A2 is a phosphate transporter. The remaining hubs (NIPBL, KDM6A, RBBP8, VPS13A) are long, broadly expressed genes, suggesting part of the co-expression reflects transcript-length or nuclear-RNA effects. Detection is high and uniform, and the module sits among other long-gene junction/polarity neighbors (M20, M46, M58).
Genes
ARHGAP32, HEPH, KDM6A, KIAA1671, MYH14, NIPBL, PLEKHA7, POF1B, RBBP8, SLC20A2, VPS13A, ZFAND3
Most correlated modules
- Long-gene nuclear transcripts · correlation 0.84
- Epithelial junction polarity · correlation 0.81
- Colonocyte differentiation signaling · correlation 0.80
- Junctional Hippo/TGF-beta signaling · correlation 0.80
- Apicobasal polarity scaffold · correlation 0.77
- STAT3/JNK signaling · correlation 0.72
- Colonocyte differentiation TFs · correlation 0.69
- Long-gene nuclear transcripts · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.