GMPPB — GDP-mannose pyrophosphorylase B
GMPPB belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GMPPB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Metabolic-Translational Coupling RNA processing & translation | APOL6, ARCN1, ARGLU1, DCAF12, DDX23, EIF2S1, EIF4G1, FHOD1 +20 more | |
| Goblet cells | UPR Chaperone Response Stress | CALR, CRELD2, LRRC59, MANF, NUCB2, P4HB, PDIA3, PDIA4 +2 more | View in SCUBA |
About the gene
| Synonyms | KIAA1851 |
|---|---|
| Chromosome | 3: 49716844-49723973 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Nucleotidyltransferase, Transferase |
Function
Catalytic subunit of the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex. Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. Can catalyze the reverse reaction in vitro. Together with GMPPA regulates GDP-alpha-D-mannose levels
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.