KDM6A — Lysine demethylase 6A
KDM6A belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KDM6A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Apical junction complex Migration & adhesion | ARHGAP32, HEPH, KIAA1671, MYH14, NIPBL, PLEKHA7, POF1B, RBBP8 +3 more | View in SCUBA |
| Gamma-delta T cells | Histone Demethylase Program DNA/chromatin regulation | BLTP3B, CHD6, ESYT2, NECAP1, PI4K2A, PSME4, RAPGEF1, RIC1 +4 more | |
| Lymphatic endothelial | Chromatin Remodeling DNA/chromatin regulation | DYRK1A, HERC1, KMT2C, MBNL1, MED13L, MRTFA, NCOA1, PDE8A +2 more | View in SCUBA |
| Macrophages | Golgi Vesicle Trafficking Vesicular traficking | ARMH3, ATG7, CCDC91, CDK17, CLASP1, COG5, COMMD10, COP1 +24 more | View in SCUBA |
About the gene
| Synonyms | UTX |
|---|---|
| Chromosome | X: 44873188-45112779 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, Dioxygenase, Oxidoreductase |
Function
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.