ADAM15 — ADAM metallopeptidase domain 15
ADAM15 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADAM15's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | SPP1 Inflammatory Activation Inflammation | ATG4A, C1orf54, C7orf50, C9orf40, CPXM2, EBF3, EIF2AK4, FKBP5 +9 more | View in SCUBA |
| Gamma-delta T cells | Effector Cell Migration migration & adhesion | ADAM8, ANXA2, APOBEC3G, CD52, CTSC, DSTN, FUT11, GLIPR2 +17 more | |
| Goblet cells | Pyroptosis Stress Response Stress | AURKAIP1, CDC37, CENPX, COMTD1, DDX39A, EEF1D, GSDMD, INF2 +6 more | View in SCUBA |
| Pericytes | Notch Vascular Development Developmental | ECSCR, HYAL2, ICAM2, JAG2, KCNN3, LYL1, MANSC1, NUDT14 +2 more | View in SCUBA |
About the gene
| Synonyms | MDC15 |
|---|---|
| Chromosome | 1: 155050566-155062775 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase, Metalloprotease, Protease |
| Biological process | Angiogenesis, Cell adhesion, Collagen degradation |
Function
Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.