PLEKHA7 — Pleckstrin homology domain containing A7
PLEKHA7 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLEKHA7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venular Inflammatory Activation Inflammation | ACKR1, AIM2, ARL4C, ASAP3, BNC2, CFP, DUSP23, FAM3D +8 more | View in SCUBA |
| Enterocytes | Apical junction complex Migration & adhesion | ARHGAP32, HEPH, KDM6A, KIAA1671, MYH14, NIPBL, POF1B, RBBP8 +3 more | View in SCUBA |
About the gene
| Synonyms | DKFZp686M22243 |
|---|---|
| Chromosome | 11: 16777297-17014415 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Required for zonula adherens biogenesis and maintenance. Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site. Mediates docking of ADAM10 to zonula adherens through a PDZD11- dependent interaction with the ADAM10-binding protein TSPAN33.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.