ER Glycoprotein Folding
Gene co-expression module in Colonocytes
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 14 of 29 genes have a known function matching the annotation |
Why this annotation
Hub genes SEC61A1 (ER translocon alpha subunit), HYOU1 (ORP150/ER chaperone for hypoxia/stress), UGGT1 (UDP-glucose glycoprotein glucosyltransferase, ER quality control), SIL1 (BiP/HSPA5 co-chaperone), GMDS (GDP-fucose synthesis), PIGT (GPI transamidase/ER), SLC39A7 (ZIP7 zinc transporter/ER), GOLM1 (Golgi membrane protein), MUC5B (gel-forming mucin), and GPX2 (glutathione peroxidase, oxidative stress) define ER protein folding, glycosylation, and GPI anchor biosynthesis with mucin production. Significantly upregulated in UC inflammation. Complements M26 (UPR chaperones) and M70 (secretory differentiation) in this ER-centered neighborhood.
Genes
Most correlated modules
- Unfolded Protein Response · correlation 0.89
- Glycan Precursor Biosynthesis · correlation 0.84
- Secretory Differentiation · correlation 0.83
- Inflammatory Regenerative State · correlation 0.81
- ER-Golgi Trafficking · correlation 0.81
- Chromatin Regulatory Response · correlation 0.80
- Inflammasome Activation · correlation 0.76
- Actin Cytoskeletal Regulation · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.