AP3B1 — Adaptor related protein complex 3 subunit beta 1
AP3B1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AP3B1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Actin Cytoskeletal Regulation Cytoskeletal | ACTR2, AP3M1, AZI2, CAPZA1, CEP250, CPSF3, DIDO1, DOCK8 +25 more | |
| Macrophages | Endosomal Vesicle Trafficking Vesicular traficking | ADAM17, ARFGEF1, ARID1B, ARK2N, ASAP1, ATF6, ATP11A, CDC73 +48 more | View in SCUBA |
| Mucosal-associated invariant T cell | Lymphocyte Migration migration & adhesion | ATP9B, BIRC6, BTBD9, CEP350, DOCK11, DOCK2, ERBIN, FRYL +8 more |
About the gene
| Synonyms | ADTB3A, HPS2 |
|---|---|
| Chromosome | 5: 78000522-78294762 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Protein transport, Transport |
Function
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.