TNXB — Tenascin XB
TNXB belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TNXB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | TGF-beta ECM Remodeling ECM remodeling | ADAM10, APLP2, CCNDBP1, CYB5R3, DHRS3, EFEMP2, GNAS, HIPK2 +10 more | View in SCUBA |
| Fibroblasts | Elastic Fiber ECM ECM production | ADD3, ASPA, FBLN5, FRMD3, PLTP, SLC29A1, SLIT2, SVEP1 | View in SCUBA |
| Lymphatic endothelial | ECM Remodeling TGFb migration & adhesion | CCDC80, CCND1, CHRDL1, CRIP1, CTSH, ECSCR, HS3ST1, IARS2 +8 more | View in SCUBA |
About the gene
| Synonyms | HXBL, TN-X, TNX, TNXB1, TNXB2, TNXBS, XB, XBS |
|---|---|
| Chromosome | 6: 32041153-32115334 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Cell adhesion |
Function
Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.