ADD3 — Adducin 3

ADD3 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ADD3's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Naive resting T cell T cell development	ACTN1, ALKBH7, ANKRD55, ARMH1, CEP170, EDAR, GCNT4, HOOK2 +7 more	View in SCUBA
Endothelial	EC Cytoskeletal Scaffold Cytoskeletal	ANTXR2, CTSD, EPB41L2, FXYD6, GYPC, MAP4K2, NRP2, RECK +2 more	View in SCUBA
Enterocytes	Spectrin-actin scaffold Cytoskeletal	DEPTOR, DNAAF9, FYB2, MBOAT2, PRKCB, SETBP1, SIPA1L2, SNTB1 +2 more	View in SCUBA
Fibroblasts	Elastic Fiber ECM ECM production	ASPA, FBLN5, FRMD3, PLTP, SLC29A1, SLIT2, SVEP1, TNXB	View in SCUBA
Gamma-delta T cells	Butyrophilin gd Activation TCR Signaling	ABI1, ANXA6, ARHGAP1, ARHGAP25, ARHGAP30, ARHGEF2, BTN3A1, BTN3A3 +16 more
Goblet cells	Mature Colonocyte Function Epithelial development	CERS6, CFTR, GAS6, LEFTY1, MAOA, NOX1, PDCD4, PLBD1 +2 more	View in SCUBA
Innate lymphoid cells	NK Homing Circulating Homing & TEM	ANXA1, APOBEC3G, C16orf54, C1orf162, CAPG, CASP4, CAST, CDKN2D +37 more	View in SCUBA
Mucosal-associated invariant T cell	Mature Effector MAIT T cell maturation	ANTKMT, APOBEC3G, CCL5, CXXC5, FHL3, GZMK, ITGA6, ITGB2 +7 more
Natural Killer cells	Cytoskeletal Remodeling Cytoskeleton & motility	ARHGAP25, ARHGEF3, C1orf21, CAPN2, CYTH1, DGKZ, DIP2A, GBP5 +4 more	View in SCUBA
Neutrophils	NET Priming State Netosis	APMAP, ARG1, CCDC125, CCPG1, ITGAM, PADI4, PLBD1, PPP2R5A +1 more

About the gene

Synonyms	ADDL
Chromosome	10: 109996368-110135565
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Predicted intracellular proteins
Molecular function	Actin-binding, Calmodulin-binding

Function

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E- cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.