Transcriptional Coactivation
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 21 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes include CREBBP (CBP, major histone acetyltransferase and transcriptional coactivator), SPEN (transcriptional repressor involved in Notch/X-inactivation), WAC (WW domain-containing adaptor involved in histone H2B ubiquitination and chromatin), PDS5A (cohesin associated factor regulating sister chromatid cohesion and gene expression), RPRD1B (regulates RNA Pol II CTD phosphorylation and transcription elongation), and TAF3 (TFIID subunit for transcription initiation). RNF10 is a ubiquitin E3 ligase with transcriptional roles. The module represents a transcriptional coactivation and chromatin-regulation program centered on CBP/CREBBP.
Genes
ATN1, ATP13A3, ATP1A1, CREBBP, FAM76B, GAK, GALNT1, MDM2, PDS5A, PI4KA, PPP1CC, RANBP9, REPS1, RNF10, RPRD1B, SLU7, SPAG9, SPEN, TAF3, TOE1, WAC
Most correlated modules
- Hypoxia Stress Response · correlation 0.88
- DNA Damage Ubiquitin · correlation 0.85
- mRNA Decay Regulation · correlation 0.85
- MAPK Kinase Signaling · correlation 0.85
- Histone Demethylase Program · correlation 0.85
- RNA Surveillance/NMD · correlation 0.84
- T Cell Migration · correlation 0.84
- Spliceosome Regulation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.