FGD5 — FYVE, RhoGEF and PH domain containing 5
FGD5 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FGD5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular EC Identity Endothelial cell development | AMOTL1, ARFGEF3, ATN1, CAMK1D, CASP10, CCNY, CFLAR, F11R +13 more | View in SCUBA |
| Macrophages | Alternative Activation Lipid Lipid metabolism | ACSL1, ADCY3, AGFG1, ARHGEF10L, ARID5B, ATP2B4, BCL6, CCL13 +24 more | View in SCUBA |
About the gene
| Synonyms | FLJ00274, FLJ39957, ZFYVE23 |
|---|---|
| Chromosome | 3: 14810853-14934571 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF- induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.