T cell cAMP Signaling
Gene co-expression module in Gamma-delta T cells
| Category | TCR Signaling |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
AP1G2 (clathrin adaptor AP-1 gamma 2, vesicle trafficking) is the top hub. PDE7A (cAMP phosphodiesterase highly expressed in T cells, modulates TCR-downstream cAMP signaling), LAX1 (lymphocyte adaptor protein scaffolding BCR/TCR signaling), CDK9 (P-TEFb transcription elongation kinase), CNOT3 (CCR4-NOT deadenylation, linking to M52 neighbor), SLC9A1 (Na+/H+ exchanger involved in T cell activation volume regulation), and GSR (glutathione reductase, redox homeostasis) collectively suggest a T cell intracellular signaling and vesicle trafficking regulatory module. The co-expression with CNOT3 connects it topologically to the RNA processing neighbor cluster.
Genes
AP1G2, ATP13A1, CCAR2, CDK9, CNOT3, GSR, LAX1, OFD1, PDE7A, RNF31, SLC9A1, SNAPC5
Most correlated modules
- EOMES Effector Program · correlation 0.86
- SR Kinase & RNA · correlation 0.77
- RNA Splicing Processing · correlation 0.74
- mRNA Splicing Regulation · correlation 0.72
- ER Protein Biogenesis · correlation 0.71
- Mitochondrial Biogenesis · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.