PDE7A — Phosphodiesterase 7A
PDE7A belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDE7A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell signaling regulators BCR/AP1/NFKb pathway | AKNA, ATF7IP, DNAJB14, FCHSD2, GOLGA4, IKZF3, INPP5D, MYCBP2 +3 more | View in SCUBA |
| CD4⁺ T cells | mRNA Splicing Factors RNA processing | ARGLU1, CDKN2D, CLK1, ERO1B, FUS, GLS, HNRNPA2B1, ID1 +8 more | View in SCUBA |
| Gamma-delta T cells | T cell cAMP Signaling TCR Signaling | AP1G2, ATP13A1, CCAR2, CDK9, CNOT3, GSR, LAX1, OFD1 +3 more | |
| Hematopoietic progenitor cells | Lymphoid Progenitor TFs Lymphcyte development | ADAM28, AFF3, ANKRD44, CYFIP2, CYLD, HLA-DMB, MEF2C, RNASEH2B +4 more | |
| Macrophages | Rho GTPase Signaling Cytoskeletal | ABCC1, ABR, ANKRD17, ARFGEF2, ARHGAP10, ARID2, ATAD2B, ATP9B +44 more | View in SCUBA |
| Mucosal-associated invariant T cell | TCR Activation Signaling TCR Signaling | ARFGEF1, ARIH1, CARD11, CCDC88C, CD226, GLS, KANSL1, KMT5B +12 more | |
| Natural Killer cells | NK Maturation Program Differentiation | ARPC5L, BAALC, CDHR1, EOMES, PDLIM1, S100PBP, SH2D1A, TESC +2 more | View in SCUBA |
About the gene
| Synonyms | HCP1 |
|---|---|
| Chromosome | 8: 65714334-65842322 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.