LAX1 — Lymphocyte transmembrane adaptor 1
LAX1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LAX1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR Activation Signaling TCR/AP1/NFKb pathway | AKNA, ATP6V1A, BCL2L11, KIF20B, NAA50, NEDD9, NPC1, PRKAR1A +6 more | View in SCUBA |
| Gamma-delta T cells | T cell cAMP Signaling TCR Signaling | AP1G2, ATP13A1, CCAR2, CDK9, CNOT3, GSR, OFD1, PDE7A +3 more | |
| Mucosal-associated invariant T cell | TCR Signal Attenuation Immune regulation | AFF4, BORCS5, CENPC, CHD2, CRACR2A, CRYBG1, DUSP16, FAS +8 more |
About the gene
| Synonyms | FLJ20340, LAX |
|---|---|
| Chromosome | 1: 203765177-203776372 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Biological process | Adaptive immunity, Immunity |
Function
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.