BCR signaling/maturation
Gene co-expression module in CD19⁺ B cells
| Category | B cell maturation |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes include several B cell signaling/maturation regulators: CD22 (inhibitory BCR co-receptor), BCL11A (B cell development TF), IL4R (B cell activation/class switch), NFATC3, CAMK2D, ITPR1 (calcium signaling downstream of BCR), CLEC2D. The module reflects B-cell intrinsic signaling and maturation programs, upregulated in inflamed CD. Core coherence with uniform B-cell expression argues for cell-state specificity rather than contamination.
Genes
ATP6V0A1, BCL11A, CAMK2D, CD22, CLEC2D, DDHD1, DGKD, IL4R, ITPR1, MDM4, NFATC3, NSD3, PIK3C2B, PLEKHA2, RERE, SLC16A7, SNX29, ZNF318
Most correlated modules
- Naive B-cell identity · correlation 0.79
- B cell identity TFs · correlation 0.79
- MHC-II antigen presentation · correlation 0.74
- Chromatin & genome maintenance · correlation 0.74
- Germinal center B-cell · correlation 0.74
- Chromatin modifiers · correlation 0.70
- B-cell signaling regulators · correlation 0.68
- mRNA splicing · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.