ITPR1 — Inositol 1,4,5-trisphosphate receptor type 1
ITPR1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ITPR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR signaling/maturation B cell maturation | ATP6V0A1, BCL11A, CAMK2D, CD22, CLEC2D, DDHD1, DGKD, IL4R +9 more | View in SCUBA |
| CD4⁺ T cells | T-cell activation TCR/AP1/NFKb pathway | C16orf87, CAMK1, CBLB, CD4, CD7, CDK6, CIAO1, COPB2 +7 more | View in SCUBA |
| Glial cells | AHR-Cytokine Activation Activation | AHR, BHLHE40, CAVIN1, CDH19, HNRNPA3, IL6ST, RBM39, SYNE1 +1 more | View in SCUBA |
| Macrophages | NF-κB AP-1 Signaling Inflammatory | ABL2, AGAP3, ARL8B, ATP1B3, ATP6V1H, B4GALT1, C5AR2, CDKN1A +21 more | View in SCUBA |
| Smooth muscle cells | STAT3 transcriptional program Activation | DDX3X, FAM210B, HLA-E, HNRNPH1, ID4, NOLC1, RAB21, STAT3 +2 more | View in SCUBA |
About the gene
| Synonyms | ACV, Insp3r1, IP3R1, PPP1R94, SCA15, SCA16, SCA29 |
|---|---|
| Chromosome | 3: 4493345-4847506 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Calcium channel, Ion channel, Ligand-gated ion channel, Receptor |
| Biological process | Apoptosis, Calcium transport, Ion transport, Transport |
Function
Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER). Undergoes conformational changes upon ligand binding, suggesting structural flexibility that allows the channel to switch from a closed state, capable of interacting with its ligands such as 1,4,5- trisphosphate and calcium, to an open state, capable of transferring calcium ions across the ER membrane (By similarity). Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CAMK2 complex (By similarity). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Regulates fertilization and egg activation by tuning the frequency and amplitude of calcium oscillations (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.