IL4R — Interleukin 4 receptor
IL4R belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL4R's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR signaling/maturation B cell maturation | ATP6V0A1, BCL11A, CAMK2D, CD22, CLEC2D, DDHD1, DGKD, ITPR1 +9 more | View in SCUBA |
| Endothelial | Wnt Angiogenic Remodeling ECM remodeling | ADAMTS4, ADGRL2, BAZ1A, FKBP11, LDLRAD3, LEF1, MTHFD2, NEURL1B +5 more | View in SCUBA |
| Fibroblasts | Hypoxia Response Stress | ACSL4, AP2S1, ARFGAP3, C4orf48, EPAS1, HIF1A, ISG20, NECTIN2 +8 more | View in SCUBA |
| Gamma-delta T cells | Naïve T Cell T cell maturation | ADK, AIF1, ARHGAP15, ARMH1, BACH2, CCR7, CNR2, DPYD +7 more | |
| Innate lymphoid cells | Antigen Processing MHC-I Immune regulation | CMTM6, GUK1, IL2RB, MYL12A, PAXX, PSMA5, PSMB8, PSMB9 +8 more | View in SCUBA |
| Neutrophils | Mature Neutrophil Identity Developmental | ALPL, CR1, CRISPLD2, NIBAN1, PXN, SH3GLB1, ST3GAL4 |
About the gene
| Synonyms | CD124 |
|---|---|
| Chromosome | 16: 27313668-27364778 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters |
| Molecular function | Receptor |
| Biological process | Immunity |
Function
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.