CLEC2D — C-type lectin domain family 2 member D
CLEC2D belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLEC2D's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR signaling/maturation B cell maturation | ATP6V0A1, BCL11A, CAMK2D, CD22, DDHD1, DGKD, IL4R, ITPR1 +9 more | View in SCUBA |
| CD4⁺ T cells | TCR early activation TCR/AP1/NFKb pathway | ARIH1, BRAF, CCNT1, ELL2, EMD, FAM133B, FOSL2, JOSD1 +11 more | View in SCUBA |
| CD8⁺ T cells | Cytotoxic Exhausted CD8 Exhaustion | CCL3, CD2BP2, CTSD, DUSP4, GZMB, NDFIP2, PHLDA1, PRF1 +2 more | View in SCUBA |
| Hematopoietic progenitor cells | Regulatory T-cell State Lymphcyte development | CYTIP, DDIT4, DOCK10, GSTA4, JCHAIN, MDFIC, MEF2A, NEGR1 +9 more |
About the gene
| Synonyms | CLAX, LLT1, OCIL |
|---|---|
| Chromosome | 12: 9664969-9699553 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
Function
Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.