BCAS3 — BCAS3 microtubule associated cell migration factor
BCAS3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BCAS3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Treg regulation Immune regulation | CDK14, CEBPA, CLNK, CNIH1, COL9A2, CPA5, FCRL3, GEM +8 more | View in SCUBA |
| Lymphatic endothelial | Cilia Centrosome Program Cytoskeletal | ARB2A, BBS9, CDKAL1, CEP112, EPB41L4A, FCHSD2, FTO, MBD5 +7 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Remodeling DNA/chromatin regulation | ANK3, ARHGAP15, ARL15, CAMKMT, CCDC91, DPYD, EDA, IMMP2L +13 more | |
| Neutrophils | ELMO-DOCK Chemotaxis Chemotaxis | CDK19, DOCK2, ELMO1, KMT2C, NCOA2, STAG1, VPS13B |
About the gene
| Synonyms | FLJ20128, PHAF2 |
|---|---|
| Chromosome | 17: 60677453-61392838 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Angiogenesis, Transcription, Transcription regulation |
Function
Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor- responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy. Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.