ARHGAP15 — Rho GTPase activating protein 15

ARHGAP15 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ARHGAP15's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Interferon Response Anti-viral	ACAP1, BCL2, CD44, CD46, DSE, EML4, FCGR2B, GATAD1 +7 more	View in SCUBA
Fibroblasts	Subepithelial Fibroblast Identity Developmental	ANGPTL1, APBB1IP, CNTN1, CP, ECM2, EFEMP1, FAM107A, FGF13 +12 more	View in SCUBA
Gamma-delta T cells	Naïve T Cell T cell maturation	ADK, AIF1, ARMH1, BACH2, CCR7, CNR2, DPYD, FAM117B +7 more
Glial cells	Myelinating Schwann Cell Myelination	ALDH1A1, CXCL12, FCGR2B, MPZ, MXRA8, NTM, PRNP, RNASE1 +1 more	View in SCUBA
Innate lymphoid cells	NK/ILC1 Identity Differentiation	ABCA5, CD37, CD96, CD99, CTSD, EPC1, GIMAP2, GIMAP6 +17 more	View in SCUBA
Mucosal-associated invariant T cell	Chromatin Remodeling DNA/chromatin regulation	ANK3, ARL15, BCAS3, CAMKMT, CCDC91, DPYD, EDA, IMMP2L +13 more
Neutrophils	Actin Cytoskeletal Remodeling Cytoskeletal	ACAP2, COP1, CUX1, DOCK8, DPYD, KDM2A, MED13L, MKLN1 +9 more
Pericytes	Pericyte Identity Differentiation Developmental	ADAMTS5, EPB41L2, GUCY1A1, INPP4B, LGI4, LMOD1, MAP1LC3A, NFASC +11 more	View in SCUBA

About the gene

Synonyms	BM046
Chromosome	2: 143091362-143768352
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Molecular function	GTPase activation

Function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.