Cilia Centrosome Program
Gene co-expression module in Lymphatic endothelial
| Category | Cytoskeletal |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 16 genes have a known function matching the annotation |
Why this annotation
CEP112 (centriole-associated), BBS9 (BBSome ciliary complex), TTC28 (tetratricopeptide repeat, cilia-related), RABGAP1L and TBC1D5 (Rab GAPs regulating vesicle/ciliary trafficking), SPIDR (DNA repair scaffold at replication forks), SMYD3 (histone methyltransferase), and FTO (m6A RNA demethylase) suggest a module centered on centrosome/cilia biology with ancillary chromatin regulation. BCAS3 is microtubule-associated. The cilia/centrosome theme is consistent with LEC biology (primary cilia in lymphatic valves). Neighbor context (M91 vesicle trafficking, M66 migration) supports a cytoskeletal/organelle program.
Genes
ARB2A, BBS9, BCAS3, CDKAL1, CEP112, EPB41L4A, FCHSD2, FTO, MBD5, RABGAP1L, SBF2, SH3D19, SMYD3, SPIDR, TBC1D5, TTC28
Most correlated modules
- Polarized Vesicle Trafficking · correlation 0.98
- Focal Adhesion Migration · correlation 0.97
- Inflammatory cAMP Response · correlation 0.95
- Lipid Metabolic Regulation · correlation 0.95
- Chromatin Remodeling · correlation 0.95
- Hippo-Adhesion Signaling · correlation 0.95
- Rho/Ras GTPase Regulation · correlation 0.95
- Actin-based Migration · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.