DPYD — Dihydropyrimidine dehydrogenase
DPYD belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DPYD's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mixed Metabolic Ambient Technical artifact | ENO2, FABP6, FCGRT, GRAP, SMURF2, SPINK2, SYNJ2BP, TNFRSF10B +1 more | View in SCUBA |
| Enterocytes | Apicobasal polarity scaffold Migration & adhesion | ADGRG7, CAMK2D, MAGI3, MAST2, MGAM2, NUMB, PATJ, PRELID2 +3 more | View in SCUBA |
| Gamma-delta T cells | Naïve T Cell T cell maturation | ADK, AIF1, ARHGAP15, ARMH1, BACH2, CCR7, CNR2, FAM117B +7 more | |
| Macrophages | Golgi Vesicle Trafficking Vesicular traficking | ARMH3, ATG7, CCDC91, CDK17, CLASP1, COG5, COMMD10, COP1 +24 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Remodeling DNA/chromatin regulation | ANK3, ARHGAP15, ARL15, BCAS3, CAMKMT, CCDC91, EDA, IMMP2L +13 more | |
| Neutrophils | Actin Cytoskeletal Remodeling Cytoskeletal | ACAP2, ARHGAP15, COP1, CUX1, DOCK8, KDM2A, MED13L, MKLN1 +9 more |
About the gene
| Synonyms | DHPDHase, DPD |
|---|---|
| Chromosome | 1: 97077743-97995000 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
Function
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.