ADH5 — Alcohol dehydrogenase 5 (class III), chi polypeptide
ADH5 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADH5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Metabolic Homeostasis Housekeeping | ALDH2, ATP2B1, ISCU, NBL1, NLGN4X, PGM1, PKIG, RAB7A +4 more | View in SCUBA |
| Goblet cells | Lipid Redox Homeostasis Housekeeping | BDH2, CASP6, DECR1, LAPTM4B, LGALS9, PAFAH1B3, THYN1, UBE2E3 | View in SCUBA |
| Mucosal-associated invariant T cell | RNA Biogenesis & Folding Housekeeping | CCT3, CTDSP1, FAM117A, FKBP1A, FKBP8, LSM4, MAT2B, MFSD10 +6 more | |
| Smooth muscle cells | Basement Membrane Matrix ECM remodeling | C4orf48, EFEMP2, FBXL7, MLXIP, MXRA8, PRNP, RTN4, VWA1 | View in SCUBA |
About the gene
| Synonyms | ADH-3, ADHX, FDH, GSNOR |
|---|---|
| Chromosome | 4: 99070978-99088801 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Lipid metabolism |
Function
Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S- nitrosoglutathione, thereby regulating protein S-nitrosylation (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.