UBE2E3 — Ubiquitin conjugating enzyme E2 E3
UBE2E3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UBE2E3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Pericyte-like Fibroblast Migration & adhesion | CDK6, CHL1, DSEL, EHD2, ENTPD1, HEPH, ITGB3, NID1 +7 more | View in SCUBA |
| Goblet cells | Lipid Redox Homeostasis Housekeeping | ADH5, BDH2, CASP6, DECR1, LAPTM4B, LGALS9, PAFAH1B3, THYN1 | View in SCUBA |
| Smooth muscle cells | Fibroblast Matrisome ECM remodeling | ADAMDEC1, EMP1, FBLN1, LTBP4, NR2F1, PLTP, PROCR, RGS10 +1 more | View in SCUBA |
About the gene
| Synonyms | UbcH9 |
|---|---|
| Chromosome | 2: 180967248-181076585 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Growth regulation, Ubl conjugation pathway |
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.