LAPTM4B — Lysosomal protein transmembrane 4 beta
LAPTM4B belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LAPTM4B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | LAYN+ tissue Treg Immune regulation | BEX3, CADM1, CHRNA6, EPHX2, FLVCR2, GNG8, IKZF4, LAYN +7 more | View in SCUBA |
| Endothelial | Hypoxia Response Stress | C1orf122, CRELD2, CSTB, EFHD2, FKBP1A, HIF1A, NECTIN2, RAB13 +3 more | View in SCUBA |
| Goblet cells | Lipid Redox Homeostasis Housekeeping | ADH5, BDH2, CASP6, DECR1, LGALS9, PAFAH1B3, THYN1, UBE2E3 | View in SCUBA |
| Smooth muscle cells | Activated Myofibroblast Activation | CNN3, EPHX1, IFI16, IGFBP4, NNMT, SERPING1, SSR4, SULF1 +3 more | View in SCUBA |
About the gene
| Synonyms | LC27 |
|---|---|
| Chromosome | 8: 97775057-97853013 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Biological process | Transport |
Function
Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.