Lipid Redox Homeostasis
Gene co-expression module in Goblet cells
| Category | Housekeeping |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes DECR1 (mitochondrial fatty acid beta-oxidation), BDH2 (ketone/iron metabolism), and ADH5 (formaldehyde/redox metabolism) anchor a lipid/redox metabolic program. CASP6, THYN1, and LGALS9 contribute apoptosis-related functions. The module is strongly downregulated in UC and CD inflammation and partially restored in remission/treatment, consistent with loss of normal epithelial metabolic competence during IBD. LAPTM4B and PAFAH1B3 support lysosomal and lipid homeostasis. Core coherence supports a single tightly co-regulated program of epithelial metabolic and redox homeostasis.
Genes
ADH5, BDH2, CASP6, DECR1, LAPTM4B, LGALS9, PAFAH1B3, THYN1, UBE2E3
Most correlated modules
- Progenitor Identity Program · correlation 0.91
- Chromatin RNA Regulation · correlation 0.89
- Colonocyte Metabolic Defense · correlation 0.87
- Chromatin Remodeling · correlation 0.84
- Mitochondrial Homeostasis · correlation 0.83
- Epithelial Maintenance · correlation 0.83
- RNA Decay Processing · correlation 0.77
- mRNA Translation Initiation · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.