BMP6 — Bone morphogenetic protein 6
BMP6 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BMP6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Neutrophils | NF-κB Signaling Inflammatory | ATP13A3, DOCK4, DSE, FLT1, HIVEP2, IRAK2, KIFC3, MAML2 +2 more |
About the gene
| Synonyms | VGR, VGR1 |
|---|---|
| Chromosome | 6: 7726099-7881728 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins |
| Molecular function | Cytokine, Developmental protein, Growth factor |
| Biological process | Chondrogenesis, Differentiation, Osteogenesis |
Function
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV. Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.